[3-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester → 3-(4-Methylpiperazin-1-YL)-5-(trifluoromethyl)aniline

Participants

Reaction Steps

Utilising the procedure described in Example 90c, but employing [3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester (Example 94a) in lieu of [3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-carbamic acid, 1,1-dimethylethyl ester, afforded the title compound as oil. 1H-NMR (400 MHz, DMSO-d6): 2.20 (s, 3H), 2.42 (m, 4H), 3.07 (m, 4H), 3.32 (br s, 2H), 5.34 (s, 1H) and 6.31 (s, 2H).

Provenance & Evidence