Dimethylformamide → HCID 11237517, compound

Participants

Reaction Steps

To a mixture of 4-[3-(6-chloro-naphthalene-2-sulfonylamino)-2-oxo-pyrrolidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (example 19, 57 mg, 0.11 mmol) in DMF (3.0 mL) at 0° C. were added potassium carbonate (50 mg) and tert-butyl bromoacetate (0.1 mL). After stirring for 2 hr, the mixture was filtered. The filtrate was purified by HPLC (60% to 100% acetonitril/water gradient) and the desired product was obtained as a solid. LC-MS found: (M+1)+=622.54.

Provenance & Evidence