反应详情

温度

80 °C

To a stirred solution of the above Compound 17a (20 mg, 0.063 mmol), aniline (7.0 μL, 0.076 mmol) and BINAP (5.6 mg, 0.009 mmol) in toluene (0.6 mL) at 25° C. was added Pd2(dba)3 (2.7 mg, 0.003 mmol) followed by NaOtBu (9.1 mg, 0.095 mmol). The solution was heated to 80° C. for 2 h. The solution was cooled, filtered and concentrated. Preparative thin layer chromatography (SiO2, 5% EtOAc/CH2Cl2) provided the title compound (12.6 mg, 0.0385 mmol, 61%).

1. temperatureThe solution was cooled
2. filtrationfiltered
3. concentrationconcentrated