HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 5-(3-aminophenyl)isoxazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl 5-(3-((tert-butoxycarbonyl)amino)phenyl)isoxazole-3-carboxylate | HCID 49775748 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 5-(3-aminophenyl)isoxazole-3-carboxylate | HCID 44819012 | 200.3% |
Reaction Steps
5-(3-tert-butoxycarbonylamino-phenyl)-isoxazole-3-carboxylic acid ethyl ester (2.63 g, 0.00791 mole) in methylene chloride. (5 mL) was treated with trifluoroacetic acid (2.5 mL) at ambient temperature for 4 hours. The mixture was concentrated in vacuo to provide the titled compound (3.68 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169797B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-ab818498796e48da9e6ca30aa09aa104 |
| Source note | uspto-grants-2007_01 |