反应详情

To 395 mg (1.62 mmol) of 3,5,3′-trimethoxybiphenyl was added 9 mL of 1.0 M BBr3 in CH2Cl2. The mixture was stirred at ambient temperature for 1.5 h, then poured over 60 mL of ice, and extracted with ethyl acetate (2×25 mL). The combined organic layers were back extracted with water (1×25 mL), then brine (1×25 mL), dried over MgSO4, filtered, and concentrated to an oil. This was heated under vacuum at 110° C. to provide the titled compound (308 mg, 94%).

1. extractionextracted with ethyl acetate (2×25 mL)
2. extractionThe combined organic layers were back extracted with water (1×25 mL)
3. dry with materialbrine (1×25 mL), dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated to an oil
6. temperatureThis was heated under vacuum at 110° C.