HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → Tert-butyl 3-(3-iodophenyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Ethyl (3-iodobenzoyl)acetate | HCID 2759369 | — |
| Product | Tert-butyl 3-(3-iodophenyl)-3-oxopropanoate | HCID 69508156 | 38% |
Reaction Steps
Ethyl 3-(3-iodophenyl)-3-oxopropanoate (29.3 g, 92.1 mmol) was heated to 120° C. in a sealed tube in t-butanol (80 mL) for 4 hours. The mixture was concentrated in vacuo and purified by column chromatography (0–3% ethyl acetate in hexanes) to provide the titled compound (12.1 g, 38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169797B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-96bea1d70b5246ef96a59b516ecb7738 |
| Source note | uspto-grants-2007_01 |