Acetyl chloride → HCID 69508183, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 4-(hydroxymethyl)-5-(3-iodophenyl)isoxazole-3-carboxylate (1.50 g, 4.03 mmol) in pyridine (5 mL) was stirred for 10 min. followed by cooling to 0° C. and slowly adding acetyl chloride (379 mg, 4.83 mmol). The mixture was allowed to come to ambient temperature and stirred for 2 hours. The solvent was removed under vacuo and the mixture purified by column chromatography (0–30% ethyl acetate in hexanes) to provide the titled compound (1.65 g, 99%).

Provenance & Evidence