Sodium Iodide → HCID 86595503, compound

Participants

Reaction Steps

1-[(4-chlorobutoxycarbonyl)-L-alanyl-(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (3.15 g, 0.0078 Mol) was dissolved in CH3CN (100 ml) and NaI (11.7 g, 0.078 Mol) was added to the solution. The mixture was refluxed for 7 h, then concentrated and diluted with CH2Cl2. The solid formed was filtered off and the organic phase was washed with H2O (3×50 ml), dried over sodium sulphate and evaporated under reduced pressure affording 1-[(4-iodobutoxycarbonyl)-L-alanyl-(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (4.03 g) as a foam that was used without further purification.

Provenance & Evidence