Pyridine, hydrofluoride (1:1) → HCID 11656125, compound

Participants

Reaction Steps

An acetonitrile (0.35 mL) solution of 7 (9 mg, 0.015 mmol) was treated with HF-pyridine (0.07 mL). The solution was allowed to stir for 2 h and then 20 mL of saturated NaHCO3 solution was added. The mixture was extracted with dichloromethane (3×15 mL) and the combined dichloromethane solution dried (Na2SO4), filtered and evaporated. Purification by preparative thin layer chromatography (50% ethyl acetate/hexanes) gave two diastereomers of diol 8 (2 mg each, 0.004 mmol each, 27% for each).

Provenance & Evidence