HCID 86600608, compound → HCID 58787677, compound

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A solution of (S)-2-(3-(5-chloro-2-methoxyphenyl)-3-fluoro-2-oxo-6-(trifluoromethyl)indoline-1-carbonyloxy)acetic acid, benzyloxycarbonylmethyl ester (XII2) (95 mg, 0.17 mmol) in methanol (50 mL) was hydrogenated with Pd—C(10%) as catalyst at room temperature. Prep. HPLC purification afforded the title compound (42.4 mg) with 98% HPLC purity (yield 53.3%). 1H NMR (CDCl3, 500 MHz) δ 8.34 (s, 1H), 7.79 (d, 1H), 7.47 (d, 1H), 7.36 (dd, 1H), 7.31 (dd, 1H), 6.76 (dd, 1H), 5.08 (d, 1H), 4.96 (d, 1H), 3.57 (s, 3H); LC-MS, 462.88 (MH+, 99%); MS (m/e) 462 (M+1).

Provenance & Evidence