Methanol → N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl) oxy]phenyl}-N'-(2-methoxyphenyl)urea

関与物質

反応条件

反応手順

2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline (100 mg) was dissolved in chloroform (10 ml), and 2-methoxyphenyl isocyanate (54 mg) was added to the solution. The mixture was stirred at 60° C. overnight. Methanol was added to the reaction solution, and the solvent was removed by distillation under the reduced pressure. The residue was purified by chromatography on silica gel by development with chloroform/acetone (6/4) to give 111 mg (yield 77%) of the title compound.

情報源と証拠