HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 69351968, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| Reactant | 4-(6,7-Dimethoxyquinazolin-4-yloxy)aniline | HCID 11616363 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 69351968 | HCID 69351968 | 36% |
Reaction Steps
4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (50 mg) was dissolved in chloroform (3 ml), and p-fluorophenyl isocyanate (23 μl) was then added to the solution. The mixture was heated under reflux overnight. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 26 mg (yield 36%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169789B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-d0d7c4dde71547ad9ba44506d721eb2e |
| Source note | uspto-grants-2007_01 |