HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-phenyl}-N'-(2-methylphenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-Tolyl isocyanate | HCID 69194 | — |
| Reactant | 4-(6,7-Dimethoxyquinazolin-4-yloxy)aniline | HCID 11616363 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-phenyl}-N'-(2-methylphenyl)urea | HCID 69351876 | 41% |
Reaction Steps
4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (50 mg) was dissolved in chloroform (3 ml), and o-toluyl isocyanate (0.25 μl) was then added to the solution. The mixture was heated under reflux overnight. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 30 mg (yield 41%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169789B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-7d9896ab246b4ac1806f20a19ddb0140 |
| Source note | uspto-grants-2007_01 |