HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-phenyl}-N'-(2-methoxyphenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| Reactant | 4-(6,7-Dimethoxyquinazolin-4-yloxy)aniline | HCID 11616363 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-phenyl}-N'-(2-methoxyphenyl)urea | HCID 22667241 | 45% |
Reaction Steps
4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (50 mg) was dissolved in chloroform (3 ml), and 2-methoxyphenyl isocyanate (27 μl) was then added to the solution. The mixture was heated under reflux overnight. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 34 mg (yield 45%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169789B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-5d0f53767417402f90c686060707ae14 |
| Source note | uspto-grants-2007_01 |