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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1375839Generated: October 29, 2026

4-Fluorophenyl isocyanate → HCID 22667045, compound

https://huagongshe.com/reaction/1375839

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenyl isocyanateHCID 70955—
Reactant2-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)anilineHCID 21889899—
SolventChloroformHCID 6212—
ProductHCID 22667045HCID 2266704581%

Reaction Conditions

Temperature60 °C

Reaction Steps

2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-aniline 50 mg) was dissolved in chloroform (5 ml), and p-fluorophenyl isocyanate (21 μl) was then added to the solution. The mixture was stirred at 60° C. for one hr. The precipitated crystal was collected by filtration and was washed to give 57 mg (yield 81%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07169789B2
Source datasetuspto-grants-2007_01
ORD IDord-c885e284710b4af88da4c1302dc5377e
Source noteuspto-grants-2007_01