Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| Reactant | 2-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)aniline | HCID 21889899 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 22667068 | HCID 22667068 | 54% |
Reaction Steps
2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-aniline 50 mg) was dissolved in chloroform (5 ml), and 2-methoxyphenyl isocyanate (24 μl) was then added to the solution. The mixture was stirred at 60° C. for one hr. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 39 mg (yield 54%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07169789B2 |
|---|
| Source dataset | uspto-grants-2007_01 |
|---|
| ORD ID | ord-b29db102e9514fd0a65f4bcb42d2fd8d |
|---|
| Source note | uspto-grants-2007_01 |
|---|
