関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Benzene, 1-isocyanato-2-methoxy- | HCID 69695 | — |
| 反応物 | 4-((6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoroaniline | HCID 21890274 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluorophenyl}-N'-(2-methoxyphenyl)urea | HCID 22667175 | 30% |
反応手順
4-((6,7-Dimethoxy-4-quinazolinyl)oxy]-2-fluoroaniline (50 mg) was dissolved in chloroform (3 ml), and 2-methoxyphenyl isocyanate (32 μl) was then added to the solution. The mixture was stirred at 60° C. overnight. Methanol was added to the reaction solution, and the mixture was purified by HPLC by development with chloroform/methanol to give 22 mg (yield 30%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07169789B2 |
|---|
| 出典データセット | uspto-grants-2007_01 |
|---|
| ORD ID | ord-107d14b7b1e2453b95822a6e4e7e6954 |
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| 出典メモ | uspto-grants-2007_01 |
|---|
