Triethylsilane → HCID 69429205, compound

Participants

Reaction Steps

To a solution of acetic acid 2-acetoxymethyl-2-acetylamino-4-(4′-hexanoyl-biphenyl-4-yl)-butyl ester (prepared according to Scheme 1) (1 mmol) in trifluoroacetic acid (10 mL) is added triethylsilane (2.5 mmol). The resulting mixture is stirred at room temperature for 12 h. After concentrating under reduced pressure, the residue is dissolved in DCM and the organic solution is washed with saturated NaHCO3 and brine and dried over Na2SO4. After concentration, the crude product is purified by column chromatography using EtOAc/hexane (1/1) to give the desired compound as a white solid. MS: (ES+): 482.3 (M+1)+.

Provenance & Evidence