Lithium Hydroxide → 2-Amino-2-[2-(4'-hexylbiphenyl-4-yl)-ethyl]propane-1,3-diol

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Reaction Steps

Acetic acid 2-acetoxymethyl-2-acetylamino-4-(4′-hexyl-biphenyl-4-yl)-butyl ester (0.2 mmol) is dissolved in THF (1 mL) and treated with 2 N LiOH aqueous solution (0.5 mL). The resulting mixture is stirred at reflux for 1 h and diluted with H2O (10 mL). It is then extracted with EtOAc (3×5 mL) and the combined organic phase is washed with brine and dried over Na2SO4. After concentrating, the crude product is purified with LC-MS to give the desired product as a white solid. MS: (ES+): 356.2 (M+1)+.

Provenance & Evidence