Triethylamine → HCID 69427789, compound

Participants

Reaction Steps

A mixture of acetic acid 2-acetoxymethyl-2-acetylamino-4-[4′-(hydroxyimino-methyl)biphenyl-4-yl]butyl ester (0.2 mmol), NaOCl (2 mmol), Et3N (3 mmol) and pentyne (40 mmol) in DCM (4 mL) and H2O (1 mL) is stirred at room temperature for 12 h. It is diluted with DCM (5 mL) and H2O (10 mL) and the organic phase is washed with brine and dried over Na2SO4. After concentrating, the crude product is purified by column chromatography using EtOAc/hexane (1/1) to give the desired product as a white solid. MS: (ES+): 507.2 (M+1)+.

Provenance & Evidence