HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1375944Generated: October 27, 2026
Ammonia → 4-[1,2,3,6-Tetrahydro-1-(phenylmethyl)-4-pyridinyl]benzenamine
https://huagongshe.com/reaction/1375944
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Benzyl-4-(4-bromophenyl)piperidin-4-ol | HCID 5333525 | — |
| Product | 4-[1,2,3,6-Tetrahydro-1-(phenylmethyl)-4-pyridinyl]benzenamine | HCID 22499416 | — |
Reaction Steps
A mixture of 4-(4-bromophenyl)-1-(phenylmethyl)-4-piperidinol (0.23 mole) and Cu2O (2 g) in aqueous ammonia (500 ml) was stirred at 180° C. for twelve hours. The mixture was cooled, extracted with DCM and washed with water. The organic layer was dried, filtered off and evaporated, yielding 60 g of 4-[1,2,3,6-tetrahydro-1-(phenylmethyl)-4-pyridinyl]benzenamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07169796B2 |
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| Source dataset | uspto-grants-2007_01 |
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| ORD ID | ord-8da8ef71488a4e1eb8e6998e02c3e399 |
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| Source note | uspto-grants-2007_01 |
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