HCID 23145989, compound → HCID 23145982, compound

HRID 13760Notes

Reaction equation

HRID 13760 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][C:10]=2[C:20]([F:23])([F:22])[F:21])[CH2:4][CH2:3]1>CO>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]=2[C:20]([F:21])([F:23])[F:22])[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 23145989HCID 23145989, compound

Product 1

HCID 23145982HCID 23145982, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared in the same manner as in Reference Example 1 (step 6), except that ethyl 4-(1-methylpiperidin-4-ylmethyl)-3-trifluoromethylbenzoate obtained in the step 1 was used, and that the crude product was mixed with methanol and stirred, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized by adding acetonitrile.

Workup

  1. customobtained in the step 1
  2. custominsolubles were removed by filtration
  3. distillationthe filtrate was distilled off under reduced pressure
  4. customthe residue was crystallized
  5. additionby adding acetonitrile

Sources & evidence

ORD record
ord-566edd5b8b8c4f61ba505a198e9a2476
Source dataset
uspto-grants-2010_06
Patent number
US07728131B2

Reaction notes

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