Hydrochloric Acid → HCID 58786178, compound

Participants

Reaction Steps

10% aqueous solution of hydrochloric acid (0.5 ml) was added to a solution of (1S)-1,5-anhydro-1-[5-(azulen-2-ylmethyl)-2,4-dimethoxyphenyl]-2,3,4,6-tetrakis-O-(methoxymethyl)-D-glucitol (0.09 g) in methanol (2.0 ml) and the mixture was refluxed with heating for 30 minutes. The reaction mixture was poured into ice-cooled water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated. The residue was purified by silica gel column chromatography (chloroform-methanol) to obtain (1S)-1,5-anhydro-1-[5-(azulen-2-ylmethyl)-2,4-dimethoxyphenyl]-D-glucitol (0.02 g).

Provenance & Evidence