関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | (S)-4-(Oxiran-2-ylmethoxy)benzonitrile | HCID 6934187 | — |
| 反応物 | Tert-butyl[2-(9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethyl]carbamate | HCID 9970422 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Azd 7009 | HCID 9876235 | 100% |
反応手順
iso-Propanol (5 mL) and water (0.5 mL) were added to [2-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl)ethyl]carbamic acid tert-butyl ester (see Example 3 (Alternative I) above; 0.43 g, 1.6 mmol) and 0.4-[(2S)-oxiranylmethoxy]benzonitrile(0.280 g, 1.6 mmol; see Preparation D above) was added. The mixture was heated at 66° C. for 19 hours (reaction was complete in 2 hours). The solvent was evaporated to dryness under reduced pressure to give the title compound as an off-white solid (0.71 g, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07169921B2 |
|---|
| 出典データセット | uspto-grants-2007_01 |
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| ORD ID | ord-c47d8baf84a64c95991e893c0b702486 |
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| 出典メモ | uspto-grants-2007_01 |
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