Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Borane | HCID 6331 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,1-Dimethylethyl 4-[2-amino-1-(2-fluorophenyl)ethyl]-1-piperazinecarboxylate | HCID 58786464 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 58786487 | HCID 58786487 | 94% |
Reaction Steps
To Ethoxycarbonylamino-1-(2-fluoro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (207) (1.05 g, 3 mmol) in THF (10 mL) at −78° C. was added 1M borane in THF (4.5 mL). The reaction is stirred at −78° C. for 1 h and then was allowed to warm to room temperature (2 h). 5N aqueous sodium hydroxide was then added and the reaction was allowed to stir for 2 h. The reaction mixture was then diluted with EtOAc and the layers are separated. The organic phase was dried with sodium sulfate and concentrated to dryness yielding 0.95 g (94%) product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07169777B2 |
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| Source dataset | uspto-grants-2007_01 |
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| ORD ID | ord-9aad269ba2724491a32c614cb4b19d8f |
|---|
| Source note | uspto-grants-2007_01 |
|---|
