Hydrogen chloride-ethyl acetate → HCID 69431998, compound

HRID 1376070Notes

Reaction equation

HRID 1376070 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:15][N:16]([C:21](=[O:23])[CH3:22])[CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:30].CCOC(C)=O>>[ClH:30].[ClH:30].[CH:24]1([CH:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:15][N:16]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:21](=[O:23])[CH3:22])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58786760HCID 58786760, compound

Product 1

HCID 69431998HCID 69431998, compound

Procedure

A solution of the product from Step I (500 mg, 1.2.1 mmol) in 1N HCl/EtOAc (25 mL) was stirred at room temperature overnight. Solvent was removed under reduced pressure and solid washed twice with Et2O to afford the title compound as a white solid. MS m/z 310.3 (M++1).

Workup

  1. customSolvent was removed under reduced pressure and solid
  2. washwashed twice with Et2O

Sources & evidence

ORD record
ord-3b814dbcb1eb47f1a70e7c269f9160d1
Source dataset
uspto-grants-2007_01
Patent number
US07169777B2

Reaction notes

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