HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl bromoacetate → tert-Butyl 3-amino-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | HCID 9203669 | HCID 9203669 | — |
| Product | tert-Butyl 3-amino-1H-indole-2-carboxylate | HCID 19360138 | — |
Reaction Steps
Follow the procedure of Example 3 (Steps B3–B5) but start with N-(2-cyano-phenyl)-2,2,2-trifluoroacetamide (synthesis described in J. Fluorine Chem. 1981, 18, (2), 185–95) and tert-butyl bromoacetate to obtain the title compound: MS 310(M+H), TLC (silica gel, dichloromethane/methanol, 7:1) Rf=0.38.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07169925B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-fca8227adf7b42cdaf49f66008a2082d |
| Source note | uspto-grants-2007_01 |