Ethanol → HCID 11652052, compound

Participants

Reaction Conditions

Reaction Steps

Reflux a mixture of 3-amino-1-(ethanoyl)-6-phenyl-1H-indole-2-carboxylic acid ethyl ester (7.3 g, 22.6 mmol) 20% aqueous potassium carbonate (100 mL) and ethanol (100 mL) for 1.75 h. Let the reaction stand at ambient temperature overnight and dilute with water (500 mL). Cool at 0° C. and collect a purple solid. Wash the solid with water and dry at 40° C. under vacuum and obtain 5.7 g of a purple solid. Triturate the solid with dichloromethane (40 mL) filter and wash the solid with dichloromethane and ethyl acetate, and then dry at 40° C. under vacuum to obtain 2.5 g of the title compound as a solid:

Provenance & Evidence