1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 10125909, compound

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Reaction Steps

5-Chloroindole-2-carboxylic acid (196 mg, 1 mmol) was dissolved in DMF (5 mL) containing 3-amino-3,4-dihydroquinolin-2(1H)-one hydrochloride (J. Med. Chem. 28, 1985, 1511–16; 162 mg, 1 mmol), EDCI (192 mg, 1 mmol) and HOBT (135 mg, 1 mmol). The mixture was stirred at ambient temperature for approximately 18 h before being partitioned between water and EtOAc. The organics were washed with water, saturated aqueous NaHCO3, saturated brine and dried over MgSO4; then filtered and evaporated to afford the title compound (212 mg, 66%) as an amorphous white solid.

Provenance & Evidence