Sodium borohydride → tert-butyl {2-[3-{[(5-chloro-1H-indol-2-yl)carbonyl]amino}-2-oxo-3,4-dihydroquinolin-1 (2H)-yl]ethyl}carbamate

Participants

Reaction Steps

Prepared using an identical procedure as for Example 44 with sodium borohydride (1298 mg, 34.3 mmol), cobalt chloride hexahydrate (1632 mg, 6.86 mmol), tert-butyldicarbonate (1497 mg, 6.86 mmol) and 5-chloro-N-[1-(cyanomethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-1H-indole-2-carboxamide (Method 11, 1299 mg, 3.43 mmol) in MeOH (15 mL) and THF (10 mL). The reaction was stirred at ambient temperature for 1.5 h to give the title compound (1560 mg, 94%) as a pale tan solid.

Provenance & Evidence