Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
15-Crown-5 → Pitolisant
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 15-Crown-5 | HCID 36336 | — |
| 반응물 | HCID 23694275 | HCID 23694275 | — |
| 반응물 | 3-(4-Chlorophenyl)propylmesylate | HCID 131726225 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Pitolisant | HCID 9948102 | — |
반응 단계
Sodium 3-piperidinopropanolate (20 mmol), 7 mmol of 3-(4-chlorophenyl)propylmesylate, and 0.5 mmol of 15-crown-5 in 30 ml of dry toluene were refluxed for 4 hours. The solvent was evaporated and the residue purified by column chromatography on silica gel (eluent: methylene chloride/methanol (90/10)). After removing the solvent under reduced pressure the residue was crystallized with oxalic acid from diethyl ether/ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07169928B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-0954cbc735564590ba89e9df01d7c926 |
| 출처 메모 | uspto-grants-2007_01 |