反应详情

7.4 g of benzyl-[2-(2-methoxy-phenoxy)-ethyl]-amine (29 mmol) were dissolved in 47 ml ethanol. To the stirred solution 10 g of 9-benzenesulfonyl-4-oxiranylmethoxy-9H-carbazole (26 mmol) were added and the mixture was heated under reflux for 15 h. The boiling solution was treated with 1 g of activated carbon for 30 min. The activated carbon was filtered off in the heat, and washed with 20 ml ethanol. The ethanol was rotary evaporated (Tbath 40° C., 20 mbar) and the crude material purified by liquid chromatography (eluent toluene/ethyl acetate 4:1), the pure fractions were collected and rotary evaporated (40° C./15 mbar).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 15 h
3. additionThe boiling solution was treated with 1 g of activated carbon for 30 min
4. filtrationThe activated carbon was filtered off in the heat
5. washwashed with 20 ml ethanol
6. customThe ethanol was rotary evaporated (Tbath 40° C., 20 mbar)
7. customthe crude material purified by liquid chromatography (eluent toluene/ethyl acetate 4:1)
8. customthe pure fractions were collected
9. customrotary evaporated (40° C./15 mbar)