t-Butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate → HCID 23145928, compound

HRID 13762Notes

Reaction equation

HRID 13762 reaction equation
[F:1][CH:2]([F:24])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[CH2:16][N:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)[C:6]([O:8]C(C)(C)C)=[O:7]>CO>[F:24][CH:2]([F:1])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:15]=1[CH2:16][N:17]1[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 1

HCID 23145963t-Butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate

Product 1

HCID 23145928HCID 23145928, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared in the same manner as in Reference Example 1 (step 6), except that t-butyl 3-difluoromethyl-4-(4-methylpiperazin-1-ylmethyl)benzoate obtained in the step 5 was used, and that the resulting crude product was mixed with methanol, insolubles were removed by filtration, the filtrate was distilled off under reduced pressure, and then the residue was crystallized from acetonitrile.

Workup

  1. customobtained in the step 5
  2. customwere removed by filtration
  3. distillationthe filtrate was distilled off under reduced pressure
  4. customthe residue was crystallized from acetonitrile

Sources & evidence

ORD record
ord-c0ec489251324a4bb24ddcc70e3ecdf7
Source dataset
uspto-grants-2010_06
Patent number
US07728131B2

Reaction notes

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