反应详情

温度

50 °C

10 g of 1-{Benzyl-[2-(2-methoxy-phenoxy)-ethyl]-amino}-3-(9H-carbazol-4-yloxy)-propan-2-ol (20 mmol) were dissolved in 80 ml methanol. 1 g of Pd-C (10%) were added and the suspension was warmed to 50° C. The mixture was hydrogenated at normal pressure for about 7 hours. The Pd-catalyst was filtered under suction and washed with 25 ml of hot methanol. 80 ml of methanol were distilled off and the residue was cooled to 0° C. and hold at this temperature for 6 h. The product was filtered and washed twice with 3 ml cold methanol. The substance was dried at 60° C. for 12 h.

1. filtrationThe Pd-catalyst was filtered under suction
2. washwashed with 25 ml of hot methanol
3. distillation80 ml of methanol were distilled off
4. temperaturethe residue was cooled to 0° C.
5. waithold at this temperature for 6 h
6. filtrationThe product was filtered
7. washwashed twice with 3 ml cold methanol
8. customThe substance was dried at 60° C. for 12 h.