Acetic Anhydride → 1-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

HRID 1376202Notes

Reaction equation

HRID 1376202 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([F:1])[CH:10]=2)[CH2:6][C:7]1=[O:11])(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-one2×

Product 1

HCID 581603571-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

At 130° C., 82.5 g of 6-fluoro-2-indolinone (starting material IV) are stirred in 180 ml acetic anhydride for 3 hours. After cooling to room temperature, the precipitate is filtered off with suction, washed with 100 ml of petroleum ether and dried.

Workup

  1. filtrationthe precipitate is filtered off with suction
  2. washwashed with 100 ml of petroleum ether
  3. customdried

Sources & evidence

ORD record
ord-e07f97adbf7c4dd69652dde546f23334
Source dataset
uspto-grants-2007_01
Patent number
US07169936B2

Reaction notes

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