Thionyl Chloride → HCID 23145938, compound

HRID 13763Notes

Reaction equation

HRID 13763 reaction equation
[F:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH2:12][CH:13]1[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]1)[C:6](O)=[O:7].S(Cl)([Cl:22])=O>>[ClH:22].[F:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH2:12][CH:13]1[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]1)[C:6]([Cl:22])=[O:7]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 231458813-Fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoic acid

Product 1

HCID 23145938HCID 23145938, compound

Procedure

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 3-fluoromethyl-4-(1-methylpiperidin-4-ylmethyl)benzoic acid obtained in the step 7 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated twice.

Workup

  1. customobtained in the step 7
  2. distillationwas distilled off under reduced pressure
  3. additionthe operation of adding of toluene to the residue
  4. customfollowed by azeotropic removal of thionyl chloride

Sources & evidence

ORD record
ord-9b4adea957564687930aab24dcb82fc0
Source dataset
uspto-grants-2010_06
Patent number
US07728131B2

Reaction notes

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