Formic Acid → HCID 22915803, compound

HRID 1376301Notes

Reaction equation

HRID 1376301 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].[CH:22]([OH:24])=O.[C:25]1(C)C=CC=C[CH:26]=1>>[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13]([CH:16]3[CH2:21][CH2:20][CH:19]([CH2:25][CH2:26][CH:22]=[O:24])[CH2:18][CH2:17]3)=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 284Formic AcidHCID 1140TolueneHCID 86748971HCID 86748971, compound

Product 1

HCID 22915803HCID 22915803, compound

Procedure

This cyclohexane derivative (11.8 g, 30 mmols) was dissolved in toluene (100 ml), followed by adding formic acid (5 ml), heating the mixture under reflux for 5 hours, washing the reaction mixture with water after completion of the stirring, drying over anhydrous magnesium sulfate, concentrating under reduced pressure and isolating the resulting yellow oil to obtain 3-(4-(4-(4-propylphenyl)phenyl)cyclohexyl)propanal. This product is used in the subsequent reaction with any purification.

Workup

  1. temperatureheating the mixture
  2. temperatureunder reflux for 5 hours
  3. washwashing the reaction mixture with water after completion of the stirring
  4. dry with materialdrying over anhydrous magnesium sulfate
  5. concentrationconcentrating under reduced pressure
  6. customisolating the resulting yellow oil

Sources & evidence

ORD record
ord-6f599b8c0d224dde8361663fffc7d3d7
Source dataset
uspto-grants-1997_09
Patent number
US05662830

Reaction notes

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