Estradiol → HCID 131720137, compound

HRID 1376315Notes

Reaction equation

[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH3:21][N+:22]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:29]([C:36]([O:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[O:37])=[C:28]2[C:23]=1[CH:24]=[CH:25][CH:26]=[CH:27]2>>[CH3:21][N+:22]1[C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:29]([C:36]([O:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[O:37])=[C:30]2[C:35]=1[CH:34]=[CH:33][CH:32]=[CH:31]2.[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@@H:14]1[CH2:13][CH2:12][C:11]3[CH:10]=[C:9]([OH:20])[CH:8]=[CH:7][C:6]=3[C@H:5]1[CH2:4][CH2:3]2

Participants

Reactant 2

HCID 5757Estradiol

HCID 1953939-Phenylcarboxylate-10-methylacridinium

Product 1

HCID 131720137HCID 131720137, compound

Procedure

incubating the activated estradiol intermediate with an acridinium ester to form an acridinium ester-17-beta-estradiol conjugate or an acridinium ester-17-beta-estradiol derivative conjugate,

Sources & evidence

ORD record: ord-6931232cb233479f89cb62cb5e78442a
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05663074

Reaction notes

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