Water → HCID 22916337, compound

Participants

Reaction Steps

1-(6-Bromohexyl)-2,4,5-triphenylimidazole (27.6 g) in dry dimethyisulphoxide (70 ml) was added over 10 minutes to a mixture of sodi-m cyanide (3.68 g) in dimethyl-sulphoxide (50 ml) and the reaction was stirred at room temperature for 20 h. The reaction mixture was poured into water (300 ml) and extracted with dichloromethane (3×150 ml). The extracts were combined, washed with water, dried over anhydrous magnesinm sulphate and evaporated to dryness in vacuo. Recrystallisation from diethyl ether and hexane gave 1-(6-cyanohexyl)-2,4,5-triphenylimidazole (24.19 g, 99%) as a white solid, m.p. 104°-6°.

Provenance & Evidence