HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(7-Ethoxycarbonyl-heptyl)-2-methyl-4,5-diphenylimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4,5-Diphenyl-2-methylimidazole | HCID 236696 | — |
| Reactant | Ethyl 8-bromooctanoate | HCID 264813 | — |
| Product | 1-(7-Ethoxycarbonyl-heptyl)-2-methyl-4,5-diphenylimidazole | HCID 22916354 | 72.1% |
Reaction Steps
2-Methyl-4,5-diphenylimidazole (2.5 g) (J. Org. Chem., 1937, 2,328) was reacted with sodium hydride (0.62 g) and ethyl 8-bromooctanoate (3.36 g) in a method similar to Example 12. Chromatography on silica gel eluted with a dichloromethane:ethanol gradient gave 1-(7-ethoxycarbonyl-heptyl)-2-methyl-4,5-diphenylimidazole (3.1 g, 72.1%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05663053 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-da315ee2f35d4fc3bca75a19ec6d17c4 |
| Source note | uspto-grants-1997_09 |