Sodium Hydroxide → HCID 22916428, compound

HRID 1376354Notes

Reaction equation

C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[C:16]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)[N:15]=[CH:14]1)=[O:5])C.[OH-].[Na+]>>[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[C:16]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)[N:15]=[CH:14]1)([OH:5])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 22916350HCID 22916350, compound

Product 1

HCID 22916428HCID 22916428, compoundYield 46%

Procedure

1-(7-Ethoxycarbonylheptyl)-4,5-bis(4-methoxyphenyl)-imidazole (0.58 g) was reacted with 2N sodium hydroxide in a method similar to Example 10. Recrystallisations from ethanol and water gave 1-(7-carboxyheptyl)-4,5-bis(4-methoxyphenyl)-imidazole (0.25 g, 46%) as a white solid, m.p. 142°-143°.

Workup

customRecrystallisations from ethanol and water

Sources & evidence

ORD record: ord-e0e7df6990c74ae499027d4376606aed
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05663053

Reaction notes

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