Diisopropylamine → Ethyl 2-benzylideneamino-2-ethylhexanoate

Beteiligte Stoffe

Reaktionsschritte

A 1.6M solution of n-butyl lithium in hexane (33 moles, Aldrich) was added to a solution of diisopropylamine (40 mmoles) in THF (21 ml) at a temperature of 5°-10° C. When addition was complete the mixture was added to a solution of the product from step (b) (30 mmoles) in THF (20 ml) at a temperature of 5°-10° C. When addition was complete, n-butyl iodide (40 mmoles) was added and the mixture allowed to warm to room temperature. After 20 hours, the mixture was poured into water/diethyl ether (1.1L/0.5L) and the organic layer separated, washed with brine (1.1L), dried and evaporated in vacuo to give the desired product as an amber liquid (100% yield).

Herkunft & Nachweise