反应详情

Chlorosulphonic acid (1 molar equivalent) was added to a solution of the product from step (f) (15 g) in dichloroethane (90 ml) at a temperature of <16° C. When addition was complete, the mixture was stirred for 2 hours at room temperature and then evaporated i vacuo. Water (60 ml) and 50% w/v aqu. NaOH (41 ml) were added and the mixture distilled at atmospheric pressure. The organic phase of the distillate was separated and dried over KOH to give a solution of the desired product (77% yield).

1. additionWhen addition
2. customevaporated i vacuo
3. additionNaOH (41 ml) were added
4. distillationthe mixture distilled at atmospheric pressure
5. customThe organic phase of the distillate was separated
6. dry with materialdried over KOH