Acetic Anhydride → HCID 22916761, compound

HRID 1376410Notes

Reaction equation

HRID 1376410 reaction equation
[C:1]([O:4][C:5](=O)[CH3:6])(=[O:3])C.[C:8]([NH:11][C:12]1[N:16](CCO)[N:15]=[CH:14][CH:13]=1)(=[O:10])[NH2:9]>C(O)=O>[C:8]([NH:11][C:12]1[N:16]([CH2:6][CH2:5][O:4][CH:1]=[O:3])[N:15]=[CH:14][CH:13]=1)(=[O:10])[NH2:9]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22916762HCID 22916762, compound

Product 1

HCID 22916761HCID 22916761, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Formic acid (2.09 ml) was added to acetic anhydride (4.17 ml) at room temperature and the mixture was stirred for 30 minutes at the same temperature. 5-Carbamoylamino-1-(2-hydroxyethyl)pyrazole (3.76 g) was added thereto under stirring and ice-cooling. The mixture was stirred for 2 hours at room temperature. The reaction mixture was evaporated in vacuo and diisopropyl ether was added thereto to give 5-carbamoylamino-1-(2-formyloxyethyl)pyrazole (4.15 g).

Workup

  1. stirringunder stirring
  2. temperatureice-cooling
  3. stirringThe mixture was stirred for 2 hours at room temperature
  4. customThe reaction mixture was evaporated in vacuo and diisopropyl ether
  5. additionwas added

Sources & evidence

ORD record
ord-df17c0ef799e48618b998cba11873f3e
Source dataset
uspto-grants-1997_09
Patent number
US05663163

Reaction notes

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