Hydrochloric Acid → HCID 131720149, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate (syn isomer) (30 g) in 4N-hydrochloric acid (22.4 ml) was added acetone (120 ml) under stirring at 20° C. The stirring was continued for 10 hours at the same temperature to give crystals, which were collected by filtration and dried to give 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido]-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolio]methyl-3-cephem-4-carboxylate hydrochloride (syn isomer) (13.46 g).

Provenance & Evidence