Potassium Carbonate → HCID 135422899, compound

Participants

Reaction Steps

A solution of 9-{[1(R)-acetoxymethyl-2(S)-cyclohexyl]methyl}guanine (0.75 mmol), aqueous methanol (2 mL) and potassium carbonate (3 eq) were stirred at room temperature for 3 hours. The reaction was concentrated and the desired compound purified by silica gel chromatography (chloroform:methanol:water 90:10:1). 1HNMR (500 mHz, d6 -DMSO); 10.44 ppm (bs, 1H); 7.66 (s, 1H); 6.39 (bs, 2H); 4.46 (t, 2H); 3.90 (m, 2H), 3.55-3.30 (m, 2H, partially obscured by water); 2.18 (m, 1H); 1.8-1.1 (m, 9H).

Provenance & Evidence