HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2-Methoxyphenyl)(3-methylphenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-Bromotoluene | HCID 11560 | — |
| Reactant | 2-Methoxybenzonitrile | HCID 81086 | — |
| Product | (2-Methoxyphenyl)(3-methylphenyl)methanone | HCID 12350165 | — |
Reaction Steps
A mixture of 2-methoxybenzonitrile (4.3 ml) and the Grignard reagent of m-bromotoluene (6.6 g) in ether was refluxed for 1 h and hydrolysed with dilute hydrochloric acid with heating. The aqueous layer was then extracted with ether, and the resultant organic layer was dried and evaporated to give the title compound (5.5 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05663179 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-5318e482e9e241e8a459f180657ab8ba |
| Source note | uspto-grants-1997_09 |