Ethylenediamine → HCID 21840467, compound

HRID 1376552Notes

Reaction equation

HRID 1376552 reaction equation
[N:1]([C:4]1[CH:13]=[C:12]([CH3:14])[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]=1[CH3:15])=[C:2]=[S:3].[CH2:16]([NH2:19])[CH2:17][NH2:18]>C1(C)C=CC=CC=1>[NH2:18][CH2:17][CH2:16][NH:19][C:2](=[S:3])[NH:1][C:4]1[CH:13]=[C:12]([CH3:14])[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5]=1[CH3:15]

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 21840471HCID 21840471, compound

Product 1

HCID 21840467HCID 21840467, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 2.0 g of 6-isothiocyanato-5,8-dimethyl-1,4-benzodioxane in 40 mL of toluene at 25° C. is added to a solution of 2.42 mL of ethylenediamine in 75 mL of toluene. After five minutes, the mixture is concentrated under reduced pressure to 20 mL at which point a solid precipitates from solution. This solid is collected and dried under vacuum to give 2.6 g of 6-[N'-(2-aminoethyl)thioureido]-5,8-dimethyl-1,4-benzodioxane as a white solid.

Workup

  1. concentrationthe mixture is concentrated under reduced pressure to 20 mL at which point a solid
  2. customprecipitates from solution
  3. customThis solid is collected
  4. customdried under vacuum

Sources & evidence

ORD record
ord-7807eb3ea1e54bc2a61a5f93b59ddf86
Source dataset
uspto-grants-1997_09
Patent number
US05663189

Reaction notes

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