Ethylenediamine → HCID 21840476, compound

HRID 1376556Notes

Reaction equation

HRID 1376556 reaction equation
[N:1]([C:4]1[CH:12]=[C:11]([CH3:13])[C:7]2[O:8][CH2:9][O:10][C:6]=2[C:5]=1[CH3:14])=[C:2]=[S:3].[CH2:15]([NH2:18])[CH2:16][NH2:17]>C1(C)C=CC=CC=1>[NH2:17][CH2:16][CH2:15][NH:18][C:2](=[S:3])[NH:1][C:4]1[CH:12]=[C:11]([CH3:13])[C:7]2[O:8][CH2:9][O:10][C:6]=2[C:5]=1[CH3:14]

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 21840478HCID 21840478, compound

Product 1

HCID 21840476HCID 21840476, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

A solution of 1.6 g of 5-isothiocyanato-4,7-dimethyl-1,3-benzodioxole in 35 mL of toluene at 25° C. is added to a solution of 1.89 g of ethylenediamine in 65 mL of toluene. The reaction gradually turns cloudy as a solid precipitates from solution. This solid is collected and dried under vacuum to give 2.0 g of 5-[N'-(2-aminoethyl)thioureido]-4,7-dimethyl-1,3-benzodioxole as a white solid.

Workup

  1. customThe reaction gradually turns cloudy as a solid
  2. customprecipitates from solution
  3. customThis solid is collected
  4. customdried under vacuum

Sources & evidence

ORD record
ord-30dddf6f7c0946989f83ed5a6cc169fe
Source dataset
uspto-grants-1997_09
Patent number
US05663189

Reaction notes

Loading…