HCID 54423976, compound → HCID 67575185, compound

HRID 1376559Notes

Reaction equation

HRID 1376559 reaction equation
[C:1]([OH:4])(=O)[CH3:2].[N:5]1([NH:10][CH:11]2[CH2:15][C:14]3[CH:16]=[CH:17][CH:18]=[C:19](C)C=3O2)[CH2:9][CH2:8][N:7]=[CH:6]1.N1(NC2CC3C=CC=C(C)C=3O2)CCN=C1.NCCNC(=S)NC1C=CC2CCOC=2C=1C>CO>[N:5]1([NH:10][C:11]2[CH:15]=[CH:14][C:16]3[CH2:2][CH2:1][O:4][C:17]=3[C:18]=2[CH3:19])[CH2:9][CH2:8][N:7]=[CH:6]1

Participants

4

Reactant 2

HCID 54423976HCID 54423976, compoundHCID 131720152HCID 131720152, compound

Product 1

HCID 67575185HCID 67575185, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-(2-Imidazolinylamino-7-methyl-2,3-dihydrobenzofuran hemiacetate. The above crude 6-[N'-(2-aminoethyl)thioureido]-7-methyl-2,3-dihydrobenzofuran is dissolved in 3 mL of methanol and treated with 0.25 g of mercuric acetate, forming a black color. The reaction mixture is stirred overnight at room temperature. The reaction mixture is filtered through celite, concentrated, and purified by silica gel chromatography to provide 0.131 g of 6-(2-imida zolinylamino)-7-methyl-2,3-dihydrobenzofuran as the hemiacerate salt.

Workup

  1. customforming a black color
  2. filtrationThe reaction mixture is filtered through celite,
  3. concentrationconcentrated
  4. custompurified by silica gel chromatography

Sources & evidence

ORD record
ord-36b023849c9844eab55aa592e8c49aea
Source dataset
uspto-grants-1997_09
Patent number
US05663189

Reaction notes

Loading…